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進捗状況

  • 各チームが決定した各サンプルの標準エピゲノムデータは IHEC へ登録されます。
  • 日本チームが IHEC へ登録した標準エピゲノムデータ(EpiRR)の状況はこちらです。
    「Complete」は IHEC が求める項目(WGBS、RNA-seq、ChIP-seq 6種)が揃っているデータです。

論文

有馬チーム

  • Varberg KM, Iqbal K, Muto M, Simon ME, Scott RL, Kozai K, Choudhury RH, Aplin JD, Biswell R, Gibson M, Okae H, Arima T, Vivian JL, Grundberg E, Soares MJ.
    ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development.
    Proc Natl Acad Sci USA. (2021) 10, e2016517118.
  • Raut B, Chen L, Hori T, Kaji H.
    An open-source add-on EVOM® device for real-time transepithelial/endothelial electrical resistance measurements in multiple transwell samples.
    Micromachines. (2021) 12, 282.
  • Shibata S, Kobayashi E, Kobayashi N, Oike A, Okae H, Arima T.
    Unique features and emerging in vitro models of human placental development.
    Reprod Med Biol. (2020) 19, 301-313.
  • Jessica KC, Sin YK, Guo Y, Hossain I, Sirois J, Russett CS, Tseng HW, Okae H, Arima T, Duchaine TF, Liu W, Pastor WA.
    Naive human embryonic stem cells can give rise to cells with a trophoblast-like transcriptome and methylome.
    Stem Cell Reports. (2020) 20, 30224.
  • Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé NG, Renaud SJ.
    Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.
    Cell Death Dis. (2020) 5, 311.
  • Bhattacharya B, Home P, Ganguly A, Ray S, Ghosh A, Islam MR, French V, Marsh C, Gunewardena S, Okae H, Arima T, Paul S.
    Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal-fetal exchange interface.
    Proc Natl Acad Sci U S A. (2020) 25,14280-14291.
  • Takahashi S, Okae H, Kobayashi N, Kitamura A, Kumada K, Yaegashi N, Arima T.
    Loss of p57KIP2 expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells.
    Proc Natl Acad Sci USA. (2019) 116, 26606-26613.
  • Hattori H, Hiura H, Kitamura A, Miyauchi N, Kobayashi N, Takahashi S, Okae H, Kyono K, Kagami M, Ogata T, Arima T.
    Association of four imprinting disorders and ART.
    Clinical Epigenetics. (2019) 1, 21.

過去の研究成果(2011-2018)